Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 μg/ml).
The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 μg/ml; fluconazole IC80, 10-30 μg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed
nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.
Kim, Keuk-Jun1, Woo Sang Sung1, Seok-Ki Moon2, Jong-Soo Choi2, Jong Guk Kim1,
and Dong Gun Lee1*
1Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea
2Department of Dermatology, College of Medicine, Yeungnam University, Daegu 705-717, Korea
Received: February 1, 2008 / Accepted: April 16, 2008